Marc Lipsitch, Nir Eyal, M. Elizabeth Halloran, Miguel A. Hernán, Ira M. Longini , Eli N. Perencevich, Rebecca F. Grais
April 3, 2015
Recent experiences in confronting the Ebola epidemic suggest principles for vaccine efficacy trials in challenging environments.
Many epidemic-prone infectious diseases present challenges that the current West African Ebola outbreak brings into sharp relief. Specifically, the urgency to evaluate vaccines, initially limited vaccine supplies, and large and unpredictable spatial and temporal fluctuations in incidence have presented huge logistical, ethical, and statistical challenges to trial design.